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Azelaic Acid vs Polyglutamic Acid: Which Is Better for Your Skin?

by Ella Goodman 11 Oct 2024

Alright, skin warriors, gather round! 

We’re diving deep into the juicy details of azelaic acid and polyglutamic acid. 

You’ve probably seen these buzzwords floating around the skincare world like confetti at a New Year’s party. 

But which one deserves that prime spot on your bathroom shelf? 

Let’s break it down in a way that even your sleep-deprived 3 AM online shopping brain can understand.

Or, you know… maybe we’re projecting there.

The Contenders: Meet Your Acids

Before we crown a winner, let’s get to know our competitors a bit better.

Azelaic Acid: The Multi-Tasking Marvel

Azelaic acid has been around like that cool indie band you finally got into—right before they got popular. 

This powerhouse is known for knocking out acne, fading hyperpigmentation, and calming inflammation like a pro. 

Derived from grains like barley and rye, it’s a naturally occurring dicarboxylic acid that your skin is more than happy to welcome.

The Key Functions

Acne Assassin: Think of azelaic acid as the secret agent targeting your acne. It reduces the proliferation of acne-causing bacteria, particularly Propionibacterium acnes. With its anti-inflammatory prowess, it doesn’t just mask blemishes—it neutralizes them right at the source.

Pigment Patrol: Hyperpigmentation doesn’t stand a chance against azelaic acid. It tackles dark spots by inhibiting tyrosinase, the enzyme responsible for melanin production. As a result, those pesky spots lighten up, revealing a more even and luminous complexion.

Inflammation Fighter: Whether it’s rosacea, redness, or just sensitivity, this acid is your skin’s best friend. Its ability to neutralize free radicals helps soothe and prevent the redness and swelling that make your face feel like a battleground.

Fun fact: Azelaic acid is one of those rare treatments that cater to all skin types and tones, not just a particular niche. That’s inclusivity at its finest!

Polyglutamic Acid: The Moisture Magnet

Polyglutamic acid (PGA) is the new kid on the block that everyone’s buzzing about. 

Extracted from natto, a fermented soybean dish from Japan, PGA’s main gig is being a hydration hero. It can hold up to 5,000 times its weight in water—take that, hyaluronic acid!

The Key Functions

Moisture Magic: PGA is like drinking an oasis after a desert marathon. It forms a film trapping water on the skin’s surface, keeping your skin perpetually hydrated. Ideal for those teetering on the brink of desert skin.

Barrier Boost: Modern life can be a skin barrier’s worst nightmare. Enter PGA, which not only locks in crucial moisture but also reinforces the skin’s natural boundary against aggressors—from pollutants to stressors. It’s like armor that’s invisible but invincible.

Smooth Operator: Reduced fine lines without fillers? Yes, please! By plumping the skin with its hydrophilic properties, PGA smooths out lines and imparts an undeniable glow, making you look fresh and fabulous around the clock.

The Science of Skin: How They Work Their Magic

In the realm of skincare, understanding how ingredients work is half the battle. Here’s a quick and dirty lowdown:

Azelaic Acid’s Mechanism

Azelaic acid works with the precision of a seasoned chef in a bustling kitchen. By interfering with tyrosinase activity, it diminishes the production of melanin, leading to a gradual fading of dark spots and discolored areas.

Simultaneously, it takes on inflammation with gusto by scavenging for free radicals and preventing the formation of reactive oxygen species. This means less redness, less irritation, and more zen for your skin.

And if that’s not enough, azelaic acid’s antimicrobial properties mean you’re putting a stop to bacterial growth—a quiet, invisible battle waging under the layers, making breakouts a distant memory.

Polyglutamic Acid’s Mechanism

PGA is where hydration meets architecture. Imagine pouring water over a sponge versus a rock. 

A rock might let water slip away, but a sponge? It absorbs and retains. That's PGA in action. Its large molecules create a water-locking film over your skin, ensuring that moisture doesn’t just evaporate into thin air.

The magic doesn’t stop there. PGA strengthens the skin’s lipid barrier, an often-overlooked but crucial line of defense. With a fortified barrier, your skin is less prone to losing moisture and more apt at keeping the nasty stuff out. That’s hydrated, healthy skin at its best.

Skin Goals: Finding Your Match Made in Skincare Heaven

Now, let’s talk skin goals. Because at the end of the day, it’s all about what you want to achieve!

Azelaic Acid: Your Go-To If...

  • You’re battling pesky pimples and stubborn acne scars: Azelaic acid steps up as your acne adversary. Whether it’s those annoying bumps or the scars they leave behind, consider this acid your go-to eraser.
  • Uneven skin tone is your nemesis and you’re on a quest for brightness: If dullness is clouding your glow, azelaic acid will brighten things up pronto. Say goodbye to spots and hello to radiance.
  • Rosacea or redness has got your cheeks in a permanent flush: Red, blotchy skin; meet your match. Azelaic acid soothes inflammation and reduces redness, leaving you with a more uniform complexion.

Polyglutamic Acid: Your Sidekick When...

  • Dry, parched skin needs a tall drink of water: PGA to the rescue! When creams and serums aren’t cutting it, this moisture magnet ensures you never see another dry patch.
  • You want to plump out fine lines and keep your complexion dewy: Get that ‘I just got a facial’ look every day. The plumping powers of PGA smooth out those pesky lines, making your skin canvas-ready.
  • Your skin barrier is crying out for love and repair: Modern life takes a toll on your skin’s barrier, but PGA is here to save the day. Fortify and protect with this hydration hero, and watch as your skin’s resilience returns from a whisper to a roar.

Layering Skincare: Can They Be BFFs?

Let’s talk besties—no, not your childhood pal, but something almost as essential: azelaic acid and polyglutamic acid.

Who says you’ve gotta pick a side? These two powerhouses can form an all-star duo if you know the ropes.

Start Slowly

When it comes to skincare, the "slow and steady" mantra is golden. 

Much like introducing a new friend to your group chat, bring azelaic acid and polyglutamic acid into your routine with a little finesse. Too much enthusiasm can overwhelm your skin, leaving it confused and irritated. 

Azelaic acid is a fantastic asset known for reducing redness and tackling breakouts, but start sparingly—aim for every other night at the outset. 

Keep an eye on how your skin reacts and adjust as necessary. Polyglutamic acid, being more hydrating, can generally play nice with your skin, but moderation remains key.

Order Matters

Why does order matter? Imagine assembling a sandwich with bread on top, veggies in the middle, and proteins somewhere in the ether. It’s a mess!

Similarly, layering your skincare products is an art. Post-cleansing, azelaic acid should make the first move. Applying it early ensures it penetrates effectively for maximum efficiency against blemishes and uneven tones. 

Only then call in polyglutamic acid—the ultimate hydration hero that seals the moisture deal. It blankets your skin, ensuring all earlier magic stays locked in place.

Patch Test

Before diving headfirst into this dynamic duo, do a patch test. 

Yep, just like testing the waters before a dip in the pool. It’s a small, simple step that can save you some major skin drama. Apply a tiny amount of each product on your forearm and wait 24 hours to see if any irritation or allergic reaction occurs. 

This precaution is your insurance policy against unwanted surprises like redness or itching.

Trick or Treat: Common Questions Debunked

With beauty routines, the questions never stop. But hey, curiosity keeps us on our toes, right? Let’s tackle your burning inquiries head-on.

Is Azelaic Acid Safe for Sensitive Skin?

Sensitive skin warriors, listen up! Azelaic acid can be your new bestie. Often hailed as a gentle giant, it’s capable of soothing irritation, calming redness, and evening out skin tone—all while playing the nice card. 

The trick? Begin with a lower concentration of 10% and observe how your skin vibes with it. If harmony prevails, gradually up the ante.

Can Polyglutamic Acid Replace Hyaluronic Acid?

While it’s tempting to crown a new king, sometimes it’s best to embrace a dual monarchy. Both polyglutamic acid (PGA) and hyaluronic acid (HA) are hydration titans, but they march to their own beats. 

HA dives deeply to quench skin thirst, while PGA reigns supreme on the surface, ensuring moisture stays put. So rather than choosing one over the other, introduce them both into your regalia for skin so hydrated it’s practically regal.

How Long Till I See Results?

Cue the meditation music and settle in, grasshopper. With azelaic acid, you’re looking at a runway of a few weeks to two months before achieving steady results. It’s all about that diligent consistency, seeing improvements like fading acne marks and even skin tone over a bit of time. 

Polyglutamic acid, on the other hand, gives you that instant burst of hydration, but its true transformation radiates over consistent use—think weeks rather than days.

Skincare Tales: Real Talk from Real Users

Enough science, let’s get to the street cred. The real proof? Stories from those who’ve lived it, seen it, slayed it.

  • Jenna, 28: “Post-breakout drama was my life—until azelaic acid entered. Dark spots, see ya never!”
  • Kyle, 34: “Post-polyglutamic acid, my skin’s taken on a ‘glazed donut’ vibe. We’re talking gloss, not grease.”
  • Emma, 23: “This tag team has leveled up my skincare game. Happy skin equals happy Emma.”

DIY Spa Night: Make the Most of Your Products

Turn your humble abode into a spa haven. We’re talking candles, your finest robe, and a lineup of skincare rockstars.

 Ready? Let’s do this.

  1. Cleanse: Kick things off with a simple cleanser to wipe away the day’s conglomerate of dust and stress.

   

  1. Tone: Prep with a balancing toner to set the stage for what’s to come.

   

  1. Azelaic Acid: Apply a thin layer responsibly—target those acne marks or pigmentation spots, let it soak in like wisdom.
  1. Polyglutamic Acid: Lock it all down. A layer of this will have your skin savoring every moment.
  1. Moisturize: Close the curtain with your moisturizer; whatever feels like home for your face.
  1. Relax: Whether you chill with tea or unwind with wine—it’s your personal moment of zen.

Get Ready to Glow

Whether azelaic acid speaks to your soul or polyglutamic acid makes your skin sing, you’re now armed with the arsenal needed to nurture the glow you’re gunning for. 

Now go on and flaunt that newfound luminescence with unapologetic confidence—your skin’s got its groove back! 

Whether you bust it out over a Zoom call or a spontaneous selfie, remember: skincare is all about love for the skin you’re in. 

Cheers to the path of your glow-up—keep shining bright!

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